看国外 | 猪肺炎支原体变异表明需要确立新术语

看国外 2019-07-05 13:59:05

The well-known bacteria Mycoplasma hyopneumoniae (M. hyo), known for causing enzootic pneumonia in swine, is in need for new terminology because of its variability.

众所周知的猪肺炎支原体 (M. hyo)是一种引起猪支原体肺炎的细菌,而眼下,由于其变异的多样性,需要一些新的术语。

That conclusion was drawn by an international team of researchers, who jointly published in Transboundary and Emerging Diseases. The authors included well-known scientists from Belgium, Spain, Argentina and the United States. In the article, they reviewed the observed variability in M. hyo, the effect it can have in swine farms and how a better terminology is possible to improve scientific communication.

这一结论是由一组国际研究人员得出的,他们共同发表在《跨境疾病与新发疾病》(Transboundary and Emerging Diseases)杂志上。作者团队由来自比利时、西班牙、阿根廷和美国的著名科学家组成。在这篇文章中,他们回顾了在猪肺炎支原体中观察到的变异、其对养猪场的影响,以及如何使用更好的术语来促进科学交流。

Proposed terminology

术语提出

The team proposed to classify the different mycoplasms by their Variable Number Tandem Repeats (VNTR)-type. In this terminology, the number of VNTRs found for 2 different surface proteins such as P97 and P146 would be used to identify the micro-organism.

研究小组建议根据不同支原体的可变数量串联重复序列(VNTR)类型对其进行分类。在本术语中,两个不同的表面蛋白如P97和P146中发现的VNTRs的数量将用于鉴定微生物。

The authors also made a call for the creation of a tool to illustrate differences and relations between VNTR-types as well as the creation and curation of a public database to inventory them all.

作者还呼吁创建一个工具来说明VNTR类型之间的差异和关系,以及创建和管理一个公共数据库来对它们进行编目。

图片1.png

Severe pneumonia in pigs that were infected with M. hyo (and PCV2). Photo: Iowa State University

感染猪肺炎支原体(和PCV2)的重症肺炎病猪。图:爱荷华州立大学

Components of the cell membrane

细胞膜的组成部分

The researchers wrote in the abstract of their article: “Different components of the cell membrane (i.e. proteins, glycoproteins and lipoproteins) may serve as adhesins and/or be toxic for the respiratory tract cells. Mechanisms leading to virulence are complex and more research is needed to identify markers for virulence. The utilisation of typing methods and complete or partial‐gene sequencing for M. hyo characterisation has increased in diagnostic laboratories as control and elimination strategies for this micro-organism are attempted worldwide.”

研究人员在文章摘要中写道:“细胞膜的不同成分(即蛋白质、糖蛋白和脂蛋白)可能作为黏附素,或者对呼吸道细胞有毒。导致毒力的机制是复杂的,需要更多的研究来确定毒力的标志物。随着世界范围内对这种微生物的控制和消除策略的尝试,诊断实验室已经增加对猪肺炎支原体特征的分型方法和完整或部分基因测序的应用。”

 “A commonly employed molecular typing method for M. hyo is Multiple‐Locus Variable number tandem repeat Analysis (MLVA). The agreement of a shared terminology and classification for the various techniques, specifically MLVA, has not been described, which makes inferences across the literature unsuitable.”

猪肺炎支原体分子分型的一种常用方法是多‐位点变量串联重复分析(MLVA)。由于没有就各种技术,特别是MLVA,达成共同的术语和分类协议,这使得对所有文献的推断都是不合适的。”

The article was written by Alyssa M. Betlach and Maria Pieters, University of Minnesota, Minneapolis, MN, USA; Dominiek Maes and Freddy Haesebrouck, University of Ghent, Belgium; Laura Garza‐Moreno and Marina Sibila, IRTA, Spain; Joaquim Segalés, Universitat Autònoma de Barcelona, Spain; Pablo Tamiozzo, Universidad Nacional de Rio Cuarto, Argentina.

本文由美国明尼苏达大学的Alyssa M. Betlach和Maria Pieters;比利时根特大学的Dominiek Maes和Freddy Haesebrouck;西班牙IRTA的Laura Garza‐Moreno和Marina Sibila;西班牙巴塞罗那自治大学的Joaquim Segalés;以及阿根廷卡托国立大学的Pablo Tamiozzo共同撰写。

来源:Pig Progress

(文/爱猪网记者刘坤颖编译,爱猪网原创,转载请注明出处)


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